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The remission of hypoxia can remodel TME (82), which can also promote the differentiation of monocytes into DC (67), promote the transformation of M2 into anti-tumor immune type M1 (67, 73), and enhance the anti-tumor activity of NK cells (65, 83).By enhancing the anti-tumor activity of immune cells and promoting the infiltration of immune cells in solid tumors, MnO 2 NPs can significantly enhance the innate immunological responses against tumor ( Figure 3 )

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4.4.1.1 Malondialdehyde as lipid peroxidation biomarkers MDA is a byproduct of the decomposition of unsaturated lipids which occurs when ROS attack polyunsaturated fatty acids, primarily derived from arachidonic acid in the cellular membrane, leading to the formation of MDA