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For toxicokinetic analysis of rat and monkey data, each animal was analyzed separately and results for each dose group were summarized as mean value and no formal statistical analysis was performed to determine the significance of the difference among the exposure groups

There are several major enzyme families involved in Phase I metabolism, including: Cytochrome P450 (CYP) enzymes : This is the most prominent family of enzymes involved in Phase I metabolism

Collection Ordering Result Interpretation Administrative Collect Preferred: 2mL Blood collected in EDTA tube

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