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Peptides offer targeted intervention addressing specific dark circle mechanisms through collagen synthesis improving skin thickness to obscure vessels, brightening compounds reducing melanin production, circulation enhancement reducing stagnant blood pooling, and anti-inflammatory effects decreasing puffiness and discoloration

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Interleukin-1

This implies that under physiological conditions, COL IV is the predominant ECM type epidermal MCs are exposed to, whereas interactions with dermal COL I and FN can occur due to altered basement membrane integrity, for instance, following injury or chronic UV exposure (Amano, 2009, 2016