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Recently, we have reported a clinical trial conducted with hospitalized HIV/TB patients in Brazil in which we evaluated the safety of NAC and its efficacy in accelerating mycobacterial clearance in sputum cultures ( Methods Ethics Statement The study was approved by the Ethics Review Committee of Fundao de Medicina Tropical Dr Heitor Vieira Dourado (FMT-HVD) (protocol study number: 60219916.5.0000.0005)

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Ultimately, what this evidence suggests, is that the whole patient and their suite of presenting signs and symptoms need to be addressed, along with elevations in homocysteine and associated methylation dysfunction

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