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During the fermentation process of cocoa powder, hydrolases secreted by microorganismssuch as lactic acid bacteria and yeastincluding glycosidases and esterasescan cleave the glycosidic or ester bonds within PCs

For instance, in colorectal cancer, blockade of the PI3K/AKT/mTOR axis can provoke aberrant Wnt/-catenin signaling as a feedback mechanism to sustain cell survival [43]